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And, for the health professionals who serve them. Many topics and insights I would now include are missing. The original concept of this treatise was to look at the main existing scientific theories of aging, see what they have in common, see what each has to say about steps that could be taken to halt or delay aging, and combine these steps into an overall "antiaging firewall.
This was a good concept and it has personally served me well. However, my thinking about health and aging has continued to become more sophisticated and nuanced and the science itself has also evolved significantly during the period.
Also, my personal anti-aging lifestyle and dietary interventions have continued to evolve in a way not captured here. I will eventually rewrite this treatise from a different perspective.
Here is a brief history of what has happened and where to look for my latest thoughts: The birth of the blog Seven years ago, I thought that I could continue to update this treatise as I followed the key scientific streams related to health and aging.
Soon, I discovered that for older people, creating health and creating longevity amount to the same thing. And, to know how to do that based on new scientific discoveries, it was necessary to consider vast, disparate and detailed bodies of scientific knowledge. Over 1 million potentially relevant scientific papers are now published every year.
It would be completely impossible to encompass even summaries of the relevant knowledge in this one treatise.
So, I created the Aging Sciences Blog as a vehicle for communicating about particularly relevant topics. The blog rapidly became my main vehicle for writing up what I have learned.
It served the initial objective of making sure that I understand a topic by forcing me to lay it out in writing in comprehensive form.
Soon, a second objective emerged for the blog - communicating this information to a wider audience, getting feedback and networking myself with other researchers. Research, communicating personally about research and writing for the blog became my major activities, and further updating of this treatise became increasingly secondary.
As time has progressed my appreciation and understanding of the detailed sciences involved in aging and health have multiplied severalfold. And yet, the more I learn the more obvious it is that there is much more yet to be learned.
It seems that for everything I learn, I discover there are at least two new things yet to be learned. Early-on, I started posting longer blog posts that go into considerable depth. The blog now July 3, includes over posts and thousands of comments.
On the average, 5, to 6, readers access the blog daily, with an average of 2. That is, there are about 14, blog accesses every day. About half of the usage is international.
Other strong and highly informed intellectual contributors have joined me in researching and authoring materials for the blog, Jim Watson in particular as a very strong partner.In the jawless fish, neural control of the heart is very primitive.
Some jawless fish, such as hagfish, rely on circulating catecholamines from diffuse chromaffin tissue to provide excitatory influences on the heart. The Dual-Control Theory of Feeding Dual-control theory was based on a homeostatic view of hunger and satiety. A decline in glucose activated the lateral hypothalamus (LH).
Jun 06, · Bulimia nervosa is an eating disorder with 5 key characteristics as noted by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM5). Recurrent episodes of binge eating. Eating more than the average person in a 2-hour period, accompanied by a sense of loss of control.
The Dual Center Theory does not explain the long term effects of lesioning of LH and VMH on the control of body weight. Alternatively, it was suggested that these cerebral nuclei tend to control hunger, satiety and ultimately the body weight through a Set-Point Mechanism (defining an optimal level).
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Sleep-wake homeostasis is an internal biochemical system that operates as a kind of timer or counter, generating a homeostatic sleep drive or pressure to sleep and regulating sleep intensity.